The outreach hub in Luckenwalde/Germany was established in the framework of a government initiative to support university knowledge and technology transfer in rural regions in 2019. Two Universities of Applied Sciences, the Technical University of Applied Sciences Wildau, the University of Applied Sciences Potsdam and the city council of Luckenwalde collaborate to initiate and run the activities of the outreach hub. With a unique profile, the outreach hub incorporates a coworking- and makerspace as well as space for exponates and with approximately 800 square meters, situated in the city center of the town to engage with the local community and to address regional needs and challenges. The outreach hub initiates and supports new opportunities for university cooperations with SMEs and civil society in the region. Within the hub a variety of participatory formats take place, like Open Lab Days in the makerspace, coworking arrangements, meetups with SME representatives, workshops with local government representatives, participative workshops with pupils from local schools, civil society, students and academic staff. The outreach hub Luckenwalde in a peripheral region has proven its important role in universities third mission strategies and triggers, promotes and especially accelerates participatory projects with the local community. In this context, an outreach hub as collaborative work space for regional actors can support the regional engagement of universities with special focus on third mission activities. With an affiliation to two universities but with different organization structures and location than the universities, the outreach hub can offer place-based and context dependent bottom-up outreach activities in collaboration with local stakeholders.